Relation Results

Summary

Name FAM83B
Full Name Protein FAM83B
Synonyms | C6orf143
Primary ID Q5T0W9
Links - -
Type protein
Relations 4
Function Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream R ...
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Type: Score: Layout: SPV 
0.20.3450.20.256FAM83BCSNK1A1LCSNK1A1CSNK1DCSNK1E

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Relations
Regulator
Mechanism
target
score ℹ
+ FAM83Bup-regulates quantity img/direct-activation.png binding CSNK1A1L 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273754 Homo sapiens HEK-293 Cell
pmid sentence
We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or required for the association of CK1 with FAM83 proteins. Our findings imply that the DUF1669 domains of FAM83 proteins anchor CK1 α, α-like, δ, and ε isoforms in specific subcellular compartments and potentially mediate their association with substrates.
Publications: 1 Organism: Homo Sapiens
+ FAM83Bup-regulates quantity img/direct-activation.png binding CSNK1A1 0.345
Identifier Residue Sequence Organism Cell Line
SIGNOR-273746 Homo sapiens HEK-293 Cell
pmid sentence
We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or required for the association of CK1 with FAM83 proteins. Our findings imply that the DUF1669 domains of FAM83 proteins anchor CK1 α, α-like, δ, and ε isoforms in specific subcellular compartments and potentially mediate their association with substrates.
Publications: 1 Organism: Homo Sapiens
+ FAM83Bup-regulates quantity img/direct-activation.png binding CSNK1D 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273766 Homo sapiens HEK-293 Cell
pmid sentence
We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or required for the association of CK1 with FAM83 proteins. Our findings imply that the DUF1669 domains of FAM83 proteins anchor CK1 α, α-like, δ, and ε isoforms in specific subcellular compartments and potentially mediate their association with substrates.
Publications: 1 Organism: Homo Sapiens
+ FAM83Bup-regulates quantity img/direct-activation.png binding CSNK1E 0.256
Identifier Residue Sequence Organism Cell Line
SIGNOR-273762 Homo sapiens HEK-293 Cell
pmid sentence
We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or required for the association of CK1 with FAM83 proteins. Our findings imply that the DUF1669 domains of FAM83 proteins anchor CK1 α, α-like, δ, and ε isoforms in specific subcellular compartments and potentially mediate their association with substrates.
Publications: 1 Organism: Homo Sapiens
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