3.0
Summary
| Name |  UBR4
|
| Full Name | E3 ubiquitin-protein ligase UBR4 |
| Synonyms | 600 kDa retinoblastoma protein-associated factor, N-recognin-4, RING-type E3 ubiquitin transferase UBR4, Retinoblastoma-associated factor of 600 kDa, RBAF600, p600, Zinc finger UBR1-type protein 1 | KIAA0462, KIAA1307, RBAF600, ZUBR1 |
| Primary ID | Q5T4S7 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. |
ubiquitination