3.0
Summary
| Name |  GKAP1View Modifications |
| Full Name | G kinase-anchoring protein 1 |
| Synonyms | cGMP-dependent protein kinase-anchoring protein of 42 kDa | GKAP42 |
| Primary ID | Q5VSY0 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKG1 |
phosphorylation
|
GKAP1 | 0.645 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | TRIM3 | down-regulates quantity by destabilization 
polyubiquitination
|
GKAP1 | 0.25 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
GKAP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |