| + |
ZFYVE26 | up-regulates activity 
binding
|
TTC19 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265542 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20208530 |
We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. On the basis of these data and the high-content microscopy described above, we propose that PtdIns(3)P controls the KIF13A-dependent recruitment of FYVE-CENT and TTC19 to the midbody, and that TTC19 is the most downstream effector of the three, possibly controlling the function of CHMP4B. FYVE-CENT binds directly to TTC19 and KIF13A. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265538 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20208530 |
We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. FYVE-CENT interacts with KIF13A and TTC19 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PIP3 | up-regulates quantity
relocalization
|
ZFYVE26 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265537 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20208530 |
We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF13A | up-regulates activity
binding
|
ZFYVE26 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265539 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20208530 |
We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. On the basis of these data and the high-content microscopy described above, we propose that PtdIns(3)P controls the KIF13A-dependent recruitment of FYVE-CENT and TTC19 to the midbody, and that TTC19 is the most downstream effector of the three, possibly controlling the function of CHMP4B. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZFYVE26
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