Relation Results

Summary

Name PYHIN1
Full Name Pyrin and HIN domain-containing protein 1
Synonyms Interferon-inducible protein X | IFIX
Primary ID Q6K0P9
Links - -
Type protein
Relations 2
Function Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads ...
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Type: Score: Layout: SPV 
0.420.294PYHIN1MDM2HDAC1

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Relations
Regulator
Mechanism
target
score ℹ
+ PYHIN1down-regulates quantity by destabilization img/direct_inhibition.png binding MDM2 0.42
Identifier Residue Sequence Organism Cell Line
SIGNOR-268493 Homo sapiens MDA-MB-468 Cell
pmid sentence
Here, we show that IFIXalpha1 downregulates HDM2, a principal negative regulator of p53, at the posttranslational level. IFIXalpha1 destabilizes HDM2 protein and promotes its ubiquitination. The E3 ligase activity of HDM2 appears to be required for this IFIXalpha1 effect. Importantly, HDM2 downregulation is required for the IFIXalpha1-mediated increase of p53 protein levels, transcriptional activity, and nuclear localization, suggesting that IFIXalpha1 positively regulates p53 by acting as a negative regulator of HDM2.
Publications: 1 Organism: Homo Sapiens
+ PYHIN1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HDAC1 0.294
Identifier Residue Sequence Organism Cell Line
SIGNOR-268495 Homo sapiens MDA-MB-468 Cell
pmid sentence
We found that maspin is selectively upregulated in IFIXα-expressing cells and involved in anti-invasive activity of IFIXα. We also present evidence indicating that IFIXα downregulates histone deacetylase 1 (HDAC1), which is possibly involved in the silencing of the maspin gene in human breast cancer cells. To confirm these results, we performed a luciferase assay using a maspin-promoter-luciferase plasmid. The results showed that HDAC1 overexpression suppressed the activity of the maspin promoter (Figure 3C). Therefore, our results suggest that IFIXα enhances maspin expression through the downregulation of HDAC1.
Publications: 1 Organism: Homo Sapiens
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