Summary

Name ERAP2
Full Name Endoplasmic reticulum aminopeptidase 2
Synonyms Leukocyte-derived arginine aminopeptidase, L-RAP | LRAP
Primary ID Q6P179
Links - -
Type protein
Relations 2
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification oligopeptide 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification peptide antigen 0.8
Publications: 1 Organism: Homo Sapiens