3.0
Summary
| Name |  ZNF322View Modifications |
| Full Name | Zinc finger protein 322 |
| Synonyms | Zinc finger protein 322A, Zinc finger protein 388, Zinc finger protein 489 | ZNF322A, ZNF388, ZNF489 |
| Primary ID | Q6U7Q0 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
ZNF322 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1D | down-regulates quantity by destabilization
phosphorylation
|
ZNF322 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXW7 | down-regulates quantity by destabilization
ubiquitination
|
ZNF322 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZNF322 | up-regulates quantity by expression 
transcriptional regulation
|
POU5F1 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ZNF322 | up-regulates quantity by expression
transcriptional regulation
|
NANOG | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |