3.0
Summary
| Name |  UNC5AView Modifications |
| Full Name | Netrin receptor UNC5A |
| Synonyms | Protein unc-5 homolog 1, Protein unc-5 homolog A | KIAA1976, UNC5H1 |
| Primary ID | Q6ZN44 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Pathways | Axon guidance |
| Function | Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | down-regulates quantity 
phosphorylation
|
UNC5A | 0.2 |
| Publications: | 2 | Organism: | Rattus Norvegicus | |
| Pathways: | Axon guidance | |||
| + | UNC5A | up-regulates activity 
binding
|
PICK1 | 0.293 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| Pathways: | Axon guidance | |||
| + | UNC5A | down-regulates activity
binding
|
DCC | 0.648 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Nervous System | |||
| Pathways: | Axon guidance | |||
| + | NTN4 | up-regulates
binding
|
UNC5A | 0.595 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UNC5A | up-regulates 
|
Chemorepulsion_of_axon | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Axon guidance | |||