+ |
USP45 | up-regulates activity
deubiquitination
|
ERCC4/ERCC1 |
0.541 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268504 |
|
|
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
25538220 |
USP45 associates with the ERCC1–XPF endonuclease. USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues. USP45 deubiquitylates ERCC1. USP45 promotes survival of cells exposed to agents that induce DNA damage responses controlled by ERCC1–XPF endonuclease |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
USP45 | up-regulates activity
deubiquitination
|
SPDL1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268505 |
|
|
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
30258100 |
Spindly is mono-ubiquitylated and this ubiquitin can be removed by active USP45. K48 ubiquitylated complex that interacts with Spindly is also de-ubiquitylated by USP45. In the absence of USP45 catalytic activity, interaction is abolished and cell migration is affected similarly to the phenotype described for lack of Spindly. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |