| + |
BRAP | down-regulates quantity by destabilization 
ubiquitination
|
BRAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272027 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23105109 |
Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRAP | down-regulates quantity by destabilization
ubiquitination
|
KSR1 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272028 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23105109 |
Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP15 | up-regulates quantity by stabilization 
deubiquitination
|
BRAP |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272030 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23105109 |
Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
BRAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP4 | up-regulates quantity by stabilization
deubiquitination
|
BRAP |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272031 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23105109 |
Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRAP | down-regulates quantity by destabilization
ubiquitination
|
USP15 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272029 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23105109 |
Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRAP | up-regulates activity
polyubiquitination
|
CDC14A |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271777 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19152073 |
Brap2 promotes Lys-63 linked ubiquitination of HsCdc14A. Collectively, these results support the idea that Brap2 facilitates Lys-63 linked ubiquitin modification of HsCdc14A, which may not be targeted for degradation, but mainly for protein–protein interactions or other regulatory functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BRAP
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