3.0
Summary
| Name |  FERMT3View Modifications |
| Full Name | Fermitin family homolog 3 |
| Synonyms | Kindlin-3, MIG2-like protein, Unc-112-related protein 2 | KIND3, MIG2B, URP2 |
| Primary ID | Q86UX7 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | up-regulates activity 
phosphorylation
|
FERMT3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FERMT3 | up-regulates activity
binding
|
ITGB1 | 0.4 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | FERMT3 | up-regulates activity
binding
|
FBLIM1 | 0.513 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | FERMT3 | up-regulates activity
binding
|
ITGB3 | 0.638 |
| Publications: | 1 | Organism: | Mus Musculus | |