| + |
ZBTB46 | up-regulates quantity by expression 
transcriptional regulation
|
PCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277987 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 30962287 |
We identified LIF/ZBTB46 signalling as a key promoter of metabolic reprogramming and NE differentiation of PCa cells through interactions with PCK1. We showed that ZBTB46 directly upregulates the expression of PCK1 and NE marker gene through activation of LIF signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZBTB46 | up-regulates 
|
Neuroendocrine cell differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277990 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 30312731 |
Most tumors progress to castration-resistant prostate cancer (CRPC) and develop the neuroendocrine (NE) phenotype under androgen deprivation therapy (ADT).Herein, we show that an immunocyte expression protein, ZBTB46, induces inflammatory response gene expression and contributes to NE differentiation of prostate cancer cells. ZBTB46 induces NE marker expressions of prostate cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZBTB46 | up-regulates quantity by expression
transcriptional regulation
|
PTGS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277991 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 30312731 |
ZBTB46 acts as a transcriptional coactivator that binds to the promoter of prostaglandin-endoperoxide synthase 1 (PTGS1) and transcriptionally regulated PTGS1 levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZBTB46 | up-regulates quantity by expression
transcriptional regulation
|
LIF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277988 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 30962287 |
ZBTB46 binds directly to the LIF regulatory sequence and enhances its transcription. Our study confirmed a novel positive association between ZBTB46 activity and LIF levels in prostate cancer tissues and cells. Under androgen regulation, low levels of ZBTB46 are an essential transcriptional factor for maintaining LIF-STAT3 signaling, while the loss of androgen signaling or inhibition of AR signaling causes LIF-enhanced therapeutic resistance and CRPC characteristics through the upregulation of ZBTB46. We also found that LIF activation drives malignant progression and NE-like reprogramming in prostate cancer by activating STAT3 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AR | down-regulates quantity by repression 
transcriptional regulation
|
ZBTB46 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277989 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 30962287 |
Our study confirmed a novel positive association between ZBTB46 activity and LIF levels in prostate cancer tissues and cells. Under androgen regulation, low levels of ZBTB46 are an essential transcriptional factor for maintaining LIF-STAT3 signaling, while the loss of androgen signaling or inhibition of AR signaling causes LIF-enhanced therapeutic resistance and CRPC characteristics through the upregulation of ZBTB46. We also found that LIF activation drives malignant progression and NE-like reprogramming in prostate cancer by activating STAT3 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZBTB46
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