3.0
Summary
| Name |  PACS2
|
| Full Name | Phosphofurin acidic cluster sorting protein 2 |
| Synonyms | PACS-2, PACS1-like protein | KIAA0602, PACS1L |
| Primary ID | Q86VP3 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
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polyubiquitination