3.0
Summary
| Name |  ZC3HC1View Modifications |
| Full Name | Nuclear-interacting partner of ALK |
| Synonyms | Nuclear-interacting partner of anaplastic lymphoma kinase, hNIPA, Zinc finger C3HC-type protein 1 | NIPA |
| Primary ID | Q86WB0 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinB/CDK1 | down-regulates 
phosphorylation
|
ZC3HC1 | 0.341 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK2 | down-regulates
phosphorylation
|
ZC3HC1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | down-regulates
phosphorylation
|
ZC3HC1 | 0.256 |
| Publications: | 1 | Organism: | Homo Sapiens | |