Summary

Name KIRREL3
Full Name Kin of IRRE-like protein 3
Synonyms Kin of irregular chiasm-like protein 3, Nephrin-like protein 2 | KIAA1867, NEPH2
Primary ID Q8IZU9
Links - -
Type protein
Relations 3
Function Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.

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Relations

Regulator Mechanism target score ℹ
+ KIRREL3up-regulates activity img/direct-activation.png binding DLG4 0.385
Publications: 1 Organism: Mus Musculus
+ KIRREL3up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ KIRREL3up-regulates activity img/direct-activation.png binding CASK 0.474
Publications: 1 Organism: Homo Sapiens
Tissue: Cerebellum