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Summary
Name
FBXL6
Full Name
F-box/LRR-repeat protein 6
Synonyms
F-box and leucine-rich repeat protein 6, F-box protein FBL6, FBL6A | FBL6
Primary ID
Q8N531
Links
-
-
Type
protein
Relations
1
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
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by mechanism
none
ubiquitination
by effect
none
up-regulates activity
by organism:
none
Homo sapiens
by tissue:
none
by cell-line
none
HuH-7 cell
Relations
Regulator
Mechanism
target
score
ℹ
+
FBXL6
up-regulates activity
ubiquitination
TKT
0.2
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-277843
Homo sapiens
HuH-7 Cell
pmid
sentence
37653031
Mechanistically, VRK2 promoted Thr287 phosphorylation of TKT and then recruited FBXL6 to promote TKT ubiquitination and activation.
Publications:
1
Organism:
Homo Sapiens