4.0
Summary
| Name |  CERS5View Modifications |
| Full Name | Ceramide synthase 5 |
| Synonyms | CerS5, LAG1 longevity assurance homolog 5, Sphingoid base N-palmitoyltransferase CERS5, EC 2.3.1.291, Sphingosine N-acyltransferase CERS5, EC 2.3.1.24 | LASS5 |
| Primary ID | Q8N5B7 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA)(PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). {ECO:0000250|UniProtKB:Q9D6K9, ECO:0000269|PubMed:16951403, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}. |
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phosphorylation