Summary

Name OTUD6B
Full Name Deubiquitinase OTUD6B
Synonyms EC 3.4.19.12, DUBA-5, OTU domain-containing protein 6B | DUBA5
Primary ID Q8N6M0
Links - -
Type protein
Relations 1
Function [Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). {ECO:0000269|PubMed:21267069, ECO:0000269|PubMed:27864334, ECO:0000269|PubMed:28343629}.; [Isoform 2]: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability. {ECO:0000269|PubMed:27864334}.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ SMURF1 img/unknown.png ubiquitination OTUD6B 0.2
Publications: 1 Organism: In Vitro