3.0
Summary
| Name |  ACOT4View Modifications |
| Full Name | Peroxisomal succinyl-coenzyme A thioesterase |
| Synonyms | EC 3.1.2.3, Acyl-coenzyme A thioesterase 4, Acyl-CoA thioesterase 4, EC 3.1.2.2, PTE-2b, Peroxisomal acyl coenzyme A thioester hydrolase Ib, Peroxisomal long-chain acyl-CoA thioesterase Ib, PTE-Ib | PTE2B, PTEIB |
| Primary ID | Q8N9L9 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157). Functions as a peroxisomal succinyl-coenzyme A thioesterase that can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157). {ECO:0000269|PubMed:16940157}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | up-regulates quantity by stabilization 
phosphorylation
|
ACOT4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates quantity by stabilization
phosphorylation
|
ACOT4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACOT4 | down-regulates quantity 
chemical modification
|
succinyl-CoA(5-) | 0.8 |
| Publications: | 1 | |||
| + | HSPA1A | down-regulates quantity by destabilization
binding
|
ACOT4 | 0.2 |
| Publications: | 1 | |||
| + | ACOT4 | up-regulates quantity
chemical modification
|
glutarate(2-) | 0.8 |
| Publications: | 1 | |||
| + | ACOT4 | up-regulates quantity
chemical modification
|
coenzyme A(4-) | 0.8 |
| Publications: | 1 | |||
| + | ACOT4 | down-regulates quantity
chemical modification
|
glutaryl-CoA(5-) | 0.8 |
| Publications: | 1 | |||