| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
PJA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270990 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYOD1 | up-regulates quantity
transcriptional regulation
|
PJA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255718 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 28067271 |
... chromatin immunoprecipitation (ChIP) analysis showed MYOD binds to a site upstream the Pja1 promoter preferentially in C2C12 cells induced to differentiate (Fig. 2c). In addition, over-expression of MyoD in human fibroblasts is sufficient to up-regulate Pja1 expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PJA1 | down-regulates quantity by destabilization 
ubiquitination
|
EZH2 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255664 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 28067271 |
Biochemical and genetic evidence demonstrates that the MYOD-induced E3 ubiquitin ligase Praja1 (PJA1) is involved in regulating EZH2 levels upon p38α activation. EZH2 premature degradation in proliferating myoblasts is prevented by low levels of PJA1, its cytoplasmic localization and the lower activity towards unphosphorylated EZH2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PJA1 | down-regulates
ubiquitination
|
SPTBN1 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16247473 |
The present study indicates that praja, a ring finger e3 ubiquitin ligase, interacts with elf and ubiquitinates it. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PJA1
- 
- 