3.0
Summary
| Name |  PIP4K2CView Modifications |
| Full Name | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma |
| Synonyms | EC 2.7.1.149, Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5, PIP4KII-gamma | PIP5K2C |
| Primary ID | Q8TBX8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439}. |
phosphorylation