Summary

Name PI4K2B
Full Name Phosphatidylinositol 4-kinase type 2-beta
Synonyms Phosphatidylinositol 4-kinase type II-beta, PI4KII-BETA |
Primary ID Q8TCG2
Links - -
Type protein
Relations 5
Inhibitors adenosine
Function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

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Relations

Regulator Mechanism target score ℹ
+ PI4K2Bup-regulates quantity img/direct-activation.png chemical modification ADP(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ PI4K2Bdown-regulates quantity img/direct_inhibition.png chemical modification ATP(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ adenosinedown-regulates activity img/direct_inhibition.png chemical inhibition PI4K2B 0.8
Publications: 1 Organism: In Vitro
+ PI4K2Bup-regulates quantity img/direct-activation.png chemical modification 1-phosphatidyl-1D-myo-inositol 4-phosphate 0.8
Publications: 1 Organism: Homo Sapiens
+ PI4K2Bdown-regulates quantity img/direct_inhibition.png chemical modification 1-phosphatidyl-1D-myo-inositol(1-) 0.8
Publications: 1 Organism: Homo Sapiens