Summary

Name MAPK15
Full Name Mitogen-activated protein kinase 15
Synonyms MAP kinase 15, MAPK 15, Extracellular signal-regulated kinase 7, ERK-7, Extracellular signal-regulated kinase 8, ERK-8 | ERK7, ERK8
Primary ID Q8TD08
Links - -
Type protein
Relations 8
Function Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK15up-regulates img/direct-activation.png phosphorylation JUN 0.43
Publications: 2 Organism: Homo Sapiens
+ PPP2CAdown-regulates img/direct_inhibition.png dephosphorylation MAPK15 0.289
Publications: 1 Organism: Homo Sapiens
+ MAPK15up-regulates img/direct-activation.png phosphorylation MAPK15 0.2
Publications: 2 Organism: Homo Sapiens
+ PTPN1down-regulates img/direct_inhibition.png dephosphorylation MAPK15 0.325
Publications: 1 Organism: Homo Sapiens
+ 17beta-estradiolup-regulates img/direct-activation.png chemical activation MAPK15 0.8
Publications: 1 Organism: Homo Sapiens
+ MAPK15down-regulates activity img/direct_inhibition.png phosphorylation ELAVL1 0.348
Publications: 1 Organism: Homo Sapiens