| + |
TBCK | up-regulates 
|
Actin_cytoskeleton_reorganization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266701 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23977024 |
Depletion of TBCK significantly inhibits cell proliferation, reduces cell size, and disrupts the organization of actin, but not microtubule. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBCK | up-regulates activity
|
mTORC1 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266699 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 33240423 |
TBCK included two types of alternatively spliced isoforms (long TBCK and short TBCK). Although there is a long way to go to fully understand the function of TBCK, recent research indicates that TBCK plays an important role in brain development. BCK deficiency would disturb activation of the mTOR complex 1 (mTORC1), thus, affecting the autophagy process and further leading to autophagosomal-lysosomal dysfunction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBCK | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23977024 |
Depletion of TBCK significantly inhibits cell proliferation, reduces cell size, and disrupts the organization of actin, but not microtubule. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TBCK
- 
- 