Summary

Name RNF139
Full Name E3 ubiquitin-protein ligase RNF139
Synonyms RING finger protein 139, RING-type E3 ubiquitin transferase RNF139, Translocation in renal carcinoma on chromosome 8 protein | TRC8
Primary ID Q8WU17
Links - -
Type protein
Relations 5
Function E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067).

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Relations

Regulator Mechanism target score ℹ
+ RNF139down-regulates quantity img/direct_inhibition.png ubiquitination INSIG1 0.494
Publications: 1 Organism: Homo Sapiens
+ RNF139down-regulates quantity img/direct_inhibition.png ubiquitination SREBF1 0.306
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF139 0.2
Publications: 1 Organism: Homo Sapiens
+ RNF139down-regulates quantity img/direct_inhibition.png ubiquitination INSIG2 0.452
Publications: 1 Organism: Homo Sapiens
+ RNF139down-regulates quantity img/direct_inhibition.png ubiquitination SREBF2 0.496
Publications: 1 Organism: Homo Sapiens