| + |
CDK1 | down-regulates activity 
phosphorylation
|
CHMP7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279446 |
Ser3 |
sPEREAEA |
Homo sapiens |
|
| pmid |
sentence |
| 34286694 |
We found that recombinant CHMP7 could be directly phosphorylated by CDK1/CCNB1 in vitro and that CDK1-phosphorylation reduced the capacity of CHMP7 to sediment (Figure 4A and B).|We identified direct CDK1 phosphorylation of CHMP7 at Ser3 and Ser441 as a suppressor of both CHMP7\u2019s ability to interact with LEM2 and its ability to assemble, as judged by sedimentation assays. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279445 |
Ser441 |
GLVPSSKsPKRQLEP |
Homo sapiens |
|
| pmid |
sentence |
| 34286694 |
We found that recombinant CHMP7 could be directly phosphorylated by CDK1/CCNB1 in vitro and that CDK1-phosphorylation reduced the capacity of CHMP7 to sediment (Figure 4A and B).|We identified direct CDK1 phosphorylation of CHMP7 at Ser3 and Ser441 as a suppressor of both CHMP7\u2019s ability to interact with LEM2 and its ability to assemble, as judged by sedimentation assays. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHMP7 | form complex 
binding
|
ESCRT-III |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265525 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
CHMP7
- 
- 