4.0
Summary
| Name |  SOCS4
|
| Full Name | Suppressor of cytokine signaling 4 |
| Synonyms | SOCS-4, Suppressor of cytokine signaling 7, SOCS-7 | SOCS7 |
| Primary ID | Q8WXH5 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. |
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