Summary

Name NCSTN
Full Name Nicastrin
Synonyms NICA_HUMAN | KIAA0253
Primary ID Q92542
Links - -
Type protein
Relations 10
Pathways Alzheimer
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PSEN1 0.964
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Alzheimer
+ up-regulates img/direct-activation.png binding PSEN2 0.939
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates img/direct-activation.png binding APH1A 0.967
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
+ form complex img/form-complex.png binding gamma-secretase 0.964
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates img/direct-activation.png binding NCSTN 0.967
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding NCSTN 0.938
Publications: 1 Organism: Homo Sapiens
Tissue: Brain