Summary

Name gamma-secretase
Primary ID SIGNOR-C98
Links CPX-2176
Type complex
Formed by PSEN1, PSENEN, NCSTN, APH1A
Relations 16
Pathways Alzheimer, FAP: Notch, NOTCH Signaling, NOTCH Signaling and Myogenesis, Tnfa_Notch_crosstalk

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding gamma-secretase 0.2
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding gamma-secretase 0.958
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH4 0.512
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding gamma-secretase 0.964
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates img/direct-activation.png cleavage NOTCH 0.665
Publications: 1
+ down-regulates quantity img/direct_inhibition.png cleavage DSCAML1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH 0.665
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH3 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH1 0.665
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png cleavage APP 0.602
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ form complex img/form-complex.png binding gamma-secretase 0.956
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates img/direct-activation.png cleavage gamma-secretase 0.956
Publications: 2 Organism: Homo Sapiens
Pathways:Alzheimer
+ down-regulates quantity img/direct_inhibition.png cleavage DSCAM 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding gamma-secretase 0.96
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH2 0.57
Publications: 1 Organism: Homo Sapiens