Relation Results

Summary

Name FIG4
Full Name Polyphosphoinositide phosphatase
Synonyms Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, SAC domain-containing protein 3 | KIAA0274, SAC3
Primary ID Q92562
Links - -
Type protein
Relations 4
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydroly ...
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Type: Score: Layout: SPV 
0.3570.9220.9310.8FIG4MCOLN1VAC14PAS complex1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)(5-)

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Relations
Regulator
Mechanism
target
score ℹ
+ FIG4up-regulates activity img/indirect-activation.png MCOLN1 0.357
Identifier Residue Sequence Organism Cell Line
SIGNOR-253536 Homo sapiens
pmid sentence
PI(3,5)P2 begins to be synthesized on endosomal membranes and is additionally required for the activation of lysosomal TRPML1/MCOLN1 channels. Thus, a deficiency of FIG4/PI(3,5)P2 would impair TRPML1/MCOLN1 channel function, leading to the accumulation of calcium in the lysosomes.
Publications: 1 Organism: Homo Sapiens
+ VAC14up-regulates quantity by stabilization img/direct-activation.png binding FIG4 0.922
Identifier Residue Sequence Organism Cell Line
SIGNOR-253534 Chlorocebus aethiops COS-7 Cell
pmid sentence
Our data indentify a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 abundance by attenuating Sac3 proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J. our data are consistent with the notion that when associated with ArPIKfyve, Sac3 is stabilized and protected from degradation, whereas in the absence of associated ArPIKfyve, Sac3 remains unfolded and, hence, prone to rapid destruction.
Publications: 1 Organism: Chlorocebus Aethiops
+ FIG4form complex img/form-complex.png binding PAS complex 0.931
Identifier Residue Sequence Organism Cell Line
SIGNOR-253528 Homo sapiens HEK-293 Cell
pmid sentence
Here we have identified and characterized Sac3, a Sac domain phosphatase, as the Fig4 mammalian counterpart. Endogenous Sac3, a widespread 97-kDa protein, formed a stable ternary complex with ArPIKfyve and PIKfyve. Sac3 assembles with PIKfyve and ArPIKfyve in a stable ternary complex and controls PtdIns(3,5)P2 levels.
Publications: 1 Organism: Homo Sapiens
+ FIG4down-regulates quantity img/direct_inhibition.png chemical modification 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)(5-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-253535 in vitro
pmid sentence
Fig4/Sac3 can decrease PI(3,5)P2 levels via its phosphatase function and also promote PI3,5P2 synthesis by acting as a secondary scaffold for the Fab1/Vac14 interaction. However, the later function appears dominant.
Publications: 1 Organism: In Vitro
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