3.0
Summary
| Name |  ARHGEF1View Modifications |
| Full Name | Rho guanine nucleotide exchange factor 1 |
| Synonyms | 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub1.5 |
| Primary ID | Q92888 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915, PubMed:9641916, PubMed:8810315, PubMed:30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | up-regulates activity 
phosphorylation
|
ARHGEF1 | 0.451 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | JAK2 | up-regulates
phosphorylation
|
ARHGEF1 | 0.332 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GNA13 | up-regulates
gtpase-activating protein, binding
|
ARHGEF1 | 0.591 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ARHGEF1 | up-regulates activity
guanine nucleotide exchange factor
|
RHOA | 0.825 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GNA13 | up-regulates activity
binding
|
ARHGEF1 | 0.591 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGEF1 | up-regulates
guanine nucleotide exchange factor
|
RHOA | 0.825 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle, Smooth Muscle | |||