Relation Results

Summary

Name USP13
Full Name Ubiquitin carboxyl-terminal hydrolase 13
Synonyms Deubiquitinating enzyme 13, Isopeptidase T-3, ISOT-3, Ubiquitin thioesterase 13, Ubiquitin-specific-processing protease 13 | ISOT3
Primary ID Q92995
Links - -
Type protein
Relations 7
Function Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as auto ...
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Type: Score: Layout: SPV 
0.6220.20.5190.5190.3580.20.277USP13UBL4ACLK3BECN1MYCMETTL3ATG5

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ USP13up-regulates activity img/direct-activation.png deubiquitination UBL4A 0.622
Identifier Residue Sequence Organism Cell Line
SIGNOR-272857 Lys48 QRLLFKGkALADGKR Homo sapiens HEK-293 Cell
pmid sentence
USP13 and gp78 control ubiquitination of Ubl4A.These data suggest that USP13 and gp78 play antagonizing roles in regulation of Ubl4A ubiquitination: While gp78 assembles ubiquitin chains on Ubl4A, USP13 antagonizes this activity to limit Ubl4A ubiquitination.Ubiquitination of Ubl4A preferentially occurs on Lys48. We identify the Bag6 cofactor Ubl4A as a shared substrate of gp78 and USP13. USP13 depletion is associated with hyper-ubiquitination of Ubl4A and altered interaction between the Bag6 complex and its co-chaperone SGTA. Because the interaction of Ubl4A with SGTA is mediated by positively-charged residues in Ubl4A including Lys48 (Chartron et al., 2012; Xu et al., 2012), which happens to be the major ubiquitination site, the simplest model to explain reduced Bag6-SGTA interaction in USP13 knockdown cells is that ubiquitin conjugates on Ubl4A sterically hinder SGTA binding.
Publications: 1 Organism: Homo Sapiens
+ CLK3up-regulates activity img/direct-activation.png phosphorylation USP13 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274122 Tyr708 EPLTMPGyGGAASAG Homo sapiens HuCCT-1 Cell
pmid sentence
CLK3 directly phosphorylated USP13 at Y708, which promoted its binding to c-Myc, thereby preventing Fbxl14-mediated c-Myc ubiquitination and activating the transcription of purine metabolic genes.
Publications: 1 Organism: Homo Sapiens
+ USP13up-regulates quantity by stabilization img/direct-activation.png deubiquitination BECN1 0.519
Identifier Residue Sequence Organism Cell Line
SIGNOR-260295 Homo sapiens HEK-293T Cell
pmid sentence
Similarly, the overexpression of USP13 reduced the levels of ubiquitinated Beclin1 which was inhibited by spautin-1 (Figure 4E)
Publications: 1 Organism: Homo Sapiens
+ BECN1up-regulates quantity by stabilization img/direct-activation.png deubiquitination USP13 0.519
Identifier Residue Sequence Organism Cell Line
SIGNOR-260296 Homo sapiens H4 Neuroglioma Cell
pmid sentence
We found that endogenous Beclin1 can interact with USP13 and the interaction was reduced in the presence of spautin-1 (Figure 5C). Interestingly, the DUB activities were significantly increased when USP13 and USP10 coincubated together or with Beclin1 or all 3 proteins together, suggesting the DUB activity can be significantly enhanced when USP13 interacts with its substrate Beclin1 or USP10.
Publications: 1 Organism: Homo Sapiens
+ USP13up-regulates quantity by stabilization img/direct-activation.png deubiquitination MYC 0.358
Identifier Residue Sequence Organism Cell Line
SIGNOR-274124 Homo sapiens Glioma Stem Cell
pmid sentence
 In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential. USP13 was preferentially expressed in GSCs, and its depletion potently inhibited GSC proliferation and tumor growth by promoting c-Myc ubiquitination and degradation.
Publications: 1 Organism: Homo Sapiens
+ METTL3up-regulates quantity by stabilization img/direct-activation.png post transcriptional regulation USP13 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275839
pmid sentence
Furthermore, N6-methyladenosine methyltransferase-like 3 (METTL3) mediated stabilization of USP13 mRNA that required the m6A reader IGF2BP2.
Publications: 1
+ USP13up-regulates quantity by stabilization img/direct-activation.png deubiquitination ATG5 0.277
Identifier Residue Sequence Organism Cell Line
SIGNOR-275838
pmid sentence
Here, we identified USP13 as an essential deubiquitinase that stabilizes ATG5 in a process that depends on the PAK1 serine/threonine-protein kinase and which enhances autophagy and promotes IM resistance in GIST cells.
Publications: 1
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