3.0
Summary
| Name |  NKD2View Modifications |
| Full Name | Protein naked cuticle homolog 2 |
| Synonyms | Naked-2, hNkd2 | |
| Primary ID | Q969F2 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PKA | up-regulates quantity by stabilization 
phosphorylation
|
NKD2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TGFA | up-regulates quantity by stabilization
binding
|
NKD2 | 0.465 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF25 | down-regulates quantity by destabilization 
polyubiquitination
|
NKD2 | 0.466 |
| Publications: | 1 | Organism: | Homo Sapiens | |