Relation Results

Name	NEIL2
Full Name	Endonuclease 8-like 2
Synonyms	EC 3.2.2.-, EC 4.2.99.18, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2 \|
Primary ID	Q969S2
Links	- -
Type	protein
Relations	1
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269\|PubMed:12097317, ECO:0000269\|PubMed:14522990, ECO:0000269\|PubMed:15175427, ECO:0000269\|PubMed:15339932}.