3.0
Summary
| Name |  FBXW5View Modifications |
| Full Name | F-box/WD repeat-containing protein 5 |
| Synonyms | F-box and WD-40 domain-containing protein 5 | FBW5 |
| Primary ID | Q969U6 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK4 | down-regulates activity 
phosphorylation
|
FBXW5 | 0.566 |
| Publications: | 1 | |||
| + | FBXW5 | down-regulates quantity by destabilization
ubiquitination
|
SASS6 | 0.559 |
| Publications: | 1 | |||
| + | APC-c | down-regulates quantity by destabilization
ubiquitination
|
FBXW5 | 0.367 |
| Publications: | 1 | |||
| + | FBXW5 | down-regulates quantity by destabilization
ubiquitination
|
SEC23B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |