| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282631 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 40083936 |
TMBIM1 was significantly upregulated in pancreatic cancer tissues and cell lines, driving pancreatic cancer cell proliferation, growth, and migration both in vitro and in vivo. Elevated TMBIM1 expression induced high infiltration of MDSCs and fostered an immunosuppressive tumor microenvironment. Mechanistically, TMBIM1 binds to the transcription factor Y box binding protein 1 (YBX1), which in turn increases the affinity of YBX1 for the PD-L1 and CCL2 gene promoters. This interaction results in their upregulation, leading to increased MDSC infiltration, thereby facilitating the immunosuppressive TIME in PDAC. |
|
4.0
TMBIM1
- 
- 
binding