Summary

Name TP53INP1
Full Name Tumor protein p53-inducible nuclear protein 1
Synonyms Stress-induced protein, p53-dependent damage-inducible nuclear protein 1, p53DINP1 | P53DINP1, SIP
Primary ID Q96A56
Links - -
Type protein
Relations 5
Function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ TP53INP1up-regulates img/direct-activation.png binding GABARAPL2 0.378
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding MAP1LC3B 0.297
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding MAP1LC3C 0.279
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding GABARAP 0.343
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding MAP1LC3A 0.346
Publications: 1 Organism: Homo Sapiens