Relation Results

Name	TIFA View Modifications
Full Name	TRAF-interacting protein with FHA domain-containing protein A
Synonyms	Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF2-binding protein \| T2BP
Primary ID	Q96CG3
Links	- -
Type	protein
Relations	3
Function	Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubMed:28877472, PubMed:28222186, PubMed:30111836). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (PubMed:15492226, PubMed:26068852). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (PubMed:30111836). {ECO:0000269\|PubMed:12566447, ECO:0000269\|PubMed:15492226, ECO:0000269\|PubMed:26068852, ECO:0000269\|PubMed:28222186, ECO:0000269\|PubMed:28877472, ECO:0000269\|PubMed:30111836}.