Summary

Name ARHGEF26
Full Name Rho guanine nucleotide exchange factor 26
Synonyms SH3 domain-containing guanine exchange factor | SGEF
Primary ID Q96DR7
Links - -
Type protein
Relations 1
Function Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

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Relations

Regulator Mechanism target score ℹ
+ ARHGEF26up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.568
Publications: 1 Organism: Homo Sapiens