Summary

Name PABIR1
Full Name PPP2R1A-PPP2R2A-interacting phosphatase regulator 1
Synonyms PABIR family member 1 | C9orf42, FAM122A
Primary ID Q96E09
Links - -
Type protein
Relations 2
Function Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation PABIR1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PPP2R2A 0.2
Publications: 1 Organism: Homo Sapiens