+ |
CHEK1 | down-regulates activity
phosphorylation
|
PABIR1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266380 |
Ser37 |
GGLRRSNsAPLIHGL |
Homo sapiens |
A-549 Cell |
pmid |
sentence |
33108758 |
Knockout of FAM122A results in activation of PP2A-B55α, a phosphatase that dephosphorylates the WEE1 protein and rescues WEE1 from ubiquitin-mediated degradation. in tumor cells with oncogene-driven replication stress, CHK1 can directly phosphorylate FAM122A, leading to activation of the PP2A-B55α phosphatase and increased WEE1 expression. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PABIR1 | down-regulates activity
binding
|
PPP2R2A |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266379 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
27588481 |
We demonstrate that the highly conserved protein in mammals, designated FAM122A, directly interacts with PP2A-Aα and B55α rather than B56α subunits, and inhibits the phosphatase activity of PP2A-Aα/B55α/Cα complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |