| + |
PPP2R2A | down-regulates activity 
binding
|
PPP2CA |
0.908 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217875 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
Since B_ suppresses the association of the catalytic C and regulatory A subunits of protein phosphatase 2A [94], the B_ interaction with the receptor is expected to result in enhanced protein phosphatase 2A activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2A | form complex 
binding
|
PP2CA_R1A_R2A |
0.896 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243430 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2A | up-regulates 
binding
|
TGFBR1 |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227517 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9774674 |
In this report, we show that another WD-40 repeat protein, the B_ subunit of protein phosphatase 2A, associates with the cytoplasmic domain of type I TGF-_ receptors. [...] We therefore conclude that B_ specifically and directly associates with the type I receptor cytoplasmic domain in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2A | up-regulates activity
binding
|
RAF1 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243417 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16239230 |
... the PP2A holoenzymes ABC and ABC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade. Furthermore both PP2A holoenzymes were found to associate with Raf1 and catalyze dephosphorylation of inhibitory phospho-Ser-259. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2A | up-regulates quantity by stabilization
dephosphorylation
|
WEE1 |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266381 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 33108758 |
Knockout of FAM122A results in activation of PP2A-B55α, a phosphatase that dephosphorylates the WEE1 protein and rescues WEE1 from ubiquitin-mediated degradation. in tumor cells with oncogene-driven replication stress, CHK1 can directly phosphorylate FAM122A, leading to activation of the PP2A-B55α phosphatase and increased WEE1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates activity
binding
|
PPP2R2A |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
The Balpha subunit interacts directly with activated T_RI. The Balpha interaction with the receptor is expected to result in enhanced protein phosphatase 2A activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2A | down-regulates activity
binding
|
AKT |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243526 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 18042541 |
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.|Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full activation. The protein phosphatase 2A (PP2A) has long been known to negatively regulate Akt activity. The PP2A holoenzyme consists of the structural |Here we report the identification of the specific B regulatory subunit that targets the PP2A holoenzyme to Akt. We found endogenous association of PP2A AB55C holoenzymes with Akt by co-immunoprecipitation analyses in pro-lymphoid FL5.12 cells.subunit (A), catalytic subunit (C), and a variable regulatory subunit (B). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PABIR1 | down-regulates activity
binding
|
PPP2R2A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266379 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 27588481 |
We demonstrate that the highly conserved protein in mammals, designated FAM122A, directly interacts with PP2A-Aα and B55α rather than B56α subunits, and inhibits the phosphatase activity of PP2A-Aα/B55α/Cα complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2A | down-regulates activity
binding
|
AKT1 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252637 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18042541 |
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.|Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full activation. The protein phosphatase 2A (PP2A) has long been known to negatively regulate Akt activity. The PP2A holoenzyme consists of the structural |Here we report the identification of the specific B regulatory subunit that targets the PP2A holoenzyme to Akt. We found endogenous association of PP2A AB55C holoenzymes with Akt by co-immunoprecipitation analyses in pro-lymphoid FL5.12 cells.subunit (A), catalytic subunit (C), and a variable regulatory subunit (B). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
PPP2R2A
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