Summary

Name RNF31
Full Name E3 ubiquitin-protein ligase RNF31
Synonyms HOIL-1-interacting protein, HOIP, RING finger protein 31, RING-type E3 ubiquitin transferase RNF31, Zinc in-between-RING-finger ubiquitin-associated domain protein | ZIBRA
Primary ID Q96EP0
Links - -
Type protein
Relations 9
Function E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:23708998).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CASP8down-regulates activity img/direct_inhibition.png cleavage RNF31 0.325
Publications: 2 Organism: Homo Sapiens
+ CASP1down-regulates activity img/direct_inhibition.png cleavage RNF31 0.2
Publications: 2 Organism: Homo Sapiens
+ RNF31up-regulates quantity by stabilization img/direct-activation.png monoubiquitination NR0B1 0.452
Publications: 1 Organism: Homo Sapiens
+ RNF31up-regulates activity img/direct-activation.png polyubiquitination CASP1 0.2
Publications: 1 Organism: Homo Sapiens
+ RNF31form complex img/form-complex.png binding LUBAC 0.944
Publications: 1 Organism: Homo Sapiens
+ RNF31up-regulates activity img/direct-activation.png polyubiquitination IKBKG 0.843
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF31 0.2
Publications: 1 Organism: Homo Sapiens