Summary

Name SMARCD1
Full Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Synonyms 60 kDa BRG-1/Brm-associated factor subunit A, BRG1-associated factor 60A, BAF60A, SWI/SNF complex 60 kDa subunit | BAF60A
Primary ID Q96GM5
Links - -
Type protein
Relations 10
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination SMARCD1 0.311
Publications: 1 Organism: Chlorocebus Aethiops
+ form complex img/form-complex.png binding Neural progenitor-specific SWI/SNF 0.803
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SWI/SNF ACTL6A-ARID1A-SMARCA2 variant 0.784
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding GBAF 0.673
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Muscle cell-specific SWI/SNF SMARCA4 variant 0.786
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ form complex img/form-complex.png binding Embryonic stem cell-specific SWI/SNF 0.747
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding SWI/SNF ACTL6B varian 0.81
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1B variant 0.786
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1A variant 0.784
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ form complex img/form-complex.png binding SWI/SNF complex 0.88
Publications: 1 Organism: Homo Sapiens