| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
RNF170 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Erlin | up-regulates activity
binding
|
RNF170 |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271918 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21610068 |
In summary, here we present evidence that RNF170 is an E3 ligase that mediates IP3 receptor ubiquitination and processing by the UPP and that it is recruited to activated IP3 receptors by the erlin1/2 complex to which it is constitutively bound. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271917 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21610068 |
In summary, here we present evidence that RNF170 is an E3 ligase that mediates IP3 receptor ubiquitination and processing by the UPP and that it is recruited to activated IP3 receptors by the erlin1/2 complex to which it is constitutively bound. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RNF170 | down-regulates activity 
polyubiquitination
|
ITPR2 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271914 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21610068 |
In summary, here we present evidence that RNF170 is an E3 ligase that mediates IP3 receptor ubiquitination and processing by the UPP and that it is recruited to activated IP3 receptors by the erlin1/2 complex to which it is constitutively bound. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF170 | down-regulates activity
polyubiquitination
|
ITPR1 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271913 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21610068 |
In summary, here we present evidence that RNF170 is an E3 ligase that mediates IP3 receptor ubiquitination and processing by the UPP and that it is recruited to activated IP3 receptors by the erlin1/2 complex to which it is constitutively bound. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RNF170
- 
- 