3.0
Summary
| Name |  ARAP1View Modifications |
| Full Name | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 |
| Synonyms | Centaurin-delta-2, Cnt-d2 | CENTD2, KIAA0782 |
| Primary ID | Q96P48 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PTK6 | up-regulates activity 
phosphorylation
|
ARAP1 | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARAP1 | down-regulates activity 
gtpase-activating protein
|
RAC1 | 0.425 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARAP1 | down-regulates activity
gtpase-activating protein
|
CDC42 | 0.508 |
| Publications: | 1 | Organism: | Homo Sapiens | |