| + |
CRBN | down-regulates quantity by destabilization 
binding, ubiquitination
|
SALL4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32071327 |
Thalidomide-induced teratogenicity is dependent on its binding to cereblon (CRBN), the substrate receptor of the Cul4A-DDB1-CRBN-RBX1 E3 ubiquitin ligase complex. Thalidomide binding to CRBN elicits subsequent ubiquitination and proteasomal degradation of CRBN neosubstrates including SALL4, a transcription factor of which polymorphisms phenocopy thalidomide-induced limb defects in humans. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272206 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32071327 |
Thalidomide-induced teratogenicity is dependent on its binding to cereblon (CRBN), the substrate receptor of the Cul4A-DDB1-CRBN-RBX1 E3 ubiquitin ligase complex. Thalidomide binding to CRBN elicits subsequent ubiquitination and proteasomal degradation of CRBN neosubstrates including SALL4, a transcription factor of which polymorphisms phenocopy thalidomide-induced limb defects in humans. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
lenalidomide | up-regulates activity 
chemical activation
|
CRBN |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236891 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26131937 |
Lenalidomide, like thalidomide and pomalidomide, binds CRBN and induces degradation of specific substrates |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CRBN |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272316 |
|
|
Homo sapiens |
MM-1 Cell |
| pmid |
sentence |
| 30026574 |
We have shown that CRBN is also targeted for degradation by SCFFbxo7 ubiquitin ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione | up-regulates activity
chemical activation
|
CRBN |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-234786 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20223979 |
We identified cereblon (CRBN) as a thalidomide-binding protein. CRBN forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cul4A that is important for limb outgrowth and expression of the fibroblast growth factor Fgf8 in zebrafish and chicks |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRBN | form complex 
binding
|
Cullin4-RBX1-DDB1 |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-234805 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22649780 |
The CUL4 family employs the structurally distinct triple WD40 ²-propeller domain-containing DDB1 adaptor to recruit members of the DDB1CUL4 associated factors (DCAF) family of substrate receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRBN | down-regulates quantity by destabilization
ubiquitination
|
IKZF3 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272319 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 29496670 |
IMiD compounds cause selective ubiquitination and degradation of IKZF1 in CD34+ cells by the CRBN E3 ubiquitin ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
thalidomide | down-regulates activity
chemical inhibition
|
CRBN |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20223979 |
Here, we identified cereblon (CRBN) as a thalidomide-binding protein. CRBN forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cul4A that is important for limb outgrowth and expression of the fibroblast growth factor Fgf8 in zebrafish and chicks. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin ligase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
pomalidomide | down-regulates activity
chemical inhibition
|
CRBN |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259283 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22552008 |
Our biophysical, biochemical and gene silencing studies show that CRBN is a proximate, therapeutically important molecular target of lenalidomide and pomalidomide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO7 | down-regulates quantity by destabilization
binding
|
CRBN |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272311 |
|
|
Homo sapiens |
MM-1 Cell |
| pmid |
sentence |
| 30026574 |
We have shown that CRBN is also targeted for degradation by SCFFbxo7 ubiquitin ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
lenalidomide | down-regulates activity
chemical inhibition
|
CRBN |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259284 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22552008 |
Our biophysical, biochemical and gene silencing studies show that CRBN is a proximate, therapeutically important molecular target of lenalidomide and pomalidomide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRBN | down-regulates quantity by destabilization
polyubiquitination
|
TP63 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272214 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 31591562 |
CRBN functions as a substrate receptor of the E3 ubiquitin ligase CRL4, whose substrate specificity is modulated by thalidomide and its analogs.When thalidomide binds to CRBN, substrate specificity of CRL4CRBN is altered and CRBN neomorphically binds to ∆Np63, TAp63 and other neosubstrates and ubiquitinates them for proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CRBN
- 
- 