| + |
CDK2 | down-regulates quantity by destabilization 
phosphorylation
|
CDX2 |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138825 |
Ser283 |
RSVPEPLsPVSSLQA |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation|We found that cyclin-dependent kinase 2 phosphorylated Cdx2 in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250728 |
Ser287 |
EPLSPVSsLQASVPG |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation|We found that cyclin-dependent kinase 2 phosphorylated Cdx2 in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250729 |
Ser291 |
PVSSLQAsVPGSVPG |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation|We found that cyclin-dependent kinase 2 phosphorylated Cdx2 in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250730 |
Ser295 |
LQASVPGsVPGVLGP |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation|We found that cyclin-dependent kinase 2 phosphorylated Cdx2 in vitro and in vivo. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
GSK3B |
phosphorylation
|
CDX2 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251227 |
Ser283 |
RSVPEPLsPVSSLQA |
in vitro |
|
| pmid |
sentence |
| 16027724 |
GSK-3, p38 and CDK2 can phosphorylate Cdx2 through the 4S motif in vitro, but only CDK2 was shown to be active in vivo. the compound mutant 4S>A (serines 281, 285, 289 and 293 replaced by alanines) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251228 |
Ser287 |
EPLSPVSsLQASVPG |
in vitro |
|
| pmid |
sentence |
| 16027724 |
GSK-3, p38 and CDK2 can phosphorylate Cdx2 through the 4S motif in vitro, but only CDK2 was shown to be active in vivo. the compound mutant 4S>A (serines 281, 285, 289 and 293 replaced by alanines) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251229 |
Ser291 |
PVSSLQAsVPGSVPG |
in vitro |
|
| pmid |
sentence |
| 16027724 |
GSK-3, p38 and CDK2 can phosphorylate Cdx2 through the 4S motif in vitro, but only CDK2 was shown to be active in vivo. the compound mutant 4S>A (serines 281, 285, 289 and 293 replaced by alanines) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251230 |
Ser295 |
LQASVPGsVPGVLGP |
in vitro |
|
| pmid |
sentence |
| 16027724 |
GSK-3, p38 and CDK2 can phosphorylate Cdx2 through the 4S motif in vitro, but only CDK2 was shown to be active in vivo. the compound mutant 4S>A (serines 281, 285, 289 and 293 replaced by alanines) |
|
| Publications: |
4 |
Organism: |
In Vitro |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
CDX2 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250092 |
Ser283 |
RSVPEPLsPVSSLQA |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250093 |
Ser287 |
EPLSPVSsLQASVPG |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250094 |
Ser291 |
PVSSLQAsVPGSVPG |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250095 |
Ser295 |
LQASVPGsVPGVLGP |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CDX2 | up-regulates quantity by expression 
transcriptional regulation
|
LCT |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253964 |
|
|
|
|
| pmid |
sentence |
| 9148757 |
By electrophoretic mobility-shift assay it was shown that the factor Cdx-2 (a homoeodomain-protein related to caudal) binds to a TTTAC sequence in the CE-LPH1. Furthermore it was demonstrated that Cdx-2 is able to activate reporter gene transcription by binding to CE-LPH1. |
|
| Publications: |
1 |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
TFF3 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253967 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 17182120 |
The transcription of human TFF3 reporter genes was significantly up-regulated by the transient overexpression of CDX2 in COS-7 cells and AGS gastric cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CDX2 | up-regulates quantity by expression 
transcriptional regulation
|
FUT2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254610 |
|
|
Homo sapiens |
HT-29 Cell, DLD-1 Cell |
| pmid |
sentence |
| 22547830 |
We provide evidence that ST3GAL1/3/4 and FUT3 are transcriptionally up-regulated by c-Myc with probable involvement of Ser62 phosphorylation, and that FUT2 is transcriptionally down-regulated through the attenuation of CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
UGT1A10 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253968 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDHX | down-regulates activity
binding
|
CDX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254904 |
|
|
Homo sapiens |
BHK-21 Cell |
| pmid |
sentence |
| 12783165 |
In the heterologous cell line BHK-21, Pdx1 inhibited by 60 to 80% the activation of the alpha-cell specific element G1 conferred by Pax-6 and/or Cdx-2/3. Although Pdx1 could bind three AT-rich motifs within G1, two of which are binding sites for Pax-6 and Cdx-2/3, the affinity of Pdx1 for G1 was much lower as compared to Pax-6. In addition, Pdx1 inhibited Pax-6 mediated activation through G3, to which Pdx1 was unable to bind. Moreover, a mutation impairing DNA binding of Pdx1 had no effect on its inhibition on Cdx-2/3. Since Pdx1 interacts directly with Pax-6 and Cdx-2/3 forming heterodimers, we suggest that Pdx1 inhibits glucagon gene transcription through protein to protein interactions with Pax-6 and Cdx-2/3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
VIL1 |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19371634 |
We concluded that cdx2 regulates intestinal villin expression through recruiting brm-type swi/snf complex to the villin promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NANOG | down-regulates quantity by repression 
transcriptional regulation
|
CDX2 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254622 |
|
|
Homo sapiens |
Embryonic Stem Cell, Embryonic Carcinoma Cell |
| pmid |
sentence |
| 15983365 |
Transfection of NANOG-specific small interfering RNAs reduced levels of NANOG transcript and protein and induced activation of the extraembryonic endoderm-associated genes GATA4, GATA6, LAMININ B1, and AFP as well as upregulation of trophectoderm-associated genes CDX2, GATA2, hCG-alpha, and hCG-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA6 | up-regulates quantity by expression
|
CDX2 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253155 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 24317510 |
Many GATA6-dependent genes lacked nearby binding sites but several strongly dependent, synexpressed and GATA6-bound genes encode TFs such as MYC, HES1, RARB and CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
UGT1A8 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253969 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 15044625 |
Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | form complex 
binding
|
CDX2/PAX6/P300 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10506141 |
In the present study, we investigated the interaction of cdx-2 and pax-6 with p300, a co-activator coupled to the basal transcription machinery. In transient transfection-expression experiments, we found that the transactivating effects of cdx-2 and pax-6 on the glucagon gene were greatly enhanced by the additional expression of p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
INS |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254906 |
|
|
Homo sapiens |
BHK-21 Cell |
| pmid |
sentence |
| 12783165 |
In the heterologous cell line BHK-21, Pdx1 inhibited by 60 to 80% the activation of the alpha-cell specific element G1 conferred by Pax-6 and/or Cdx-2/3. Although Pdx1 could bind three AT-rich motifs within G1, two of which are binding sites for Pax-6 and Cdx-2/3, the affinity of Pdx1 for G1 was much lower as compared to Pax-6. In addition, Pdx1 inhibited Pax-6 mediated activation through G3, to which Pdx1 was unable to bind. Moreover, a mutation impairing DNA binding of Pdx1 had no effect on its inhibition on Cdx-2/3. Since Pdx1 interacts directly with Pax-6 and Cdx-2/3 forming heterodimers, we suggest that Pdx1 inhibits glucagon gene transcription through protein to protein interactions with Pax-6 and Cdx-2/3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
CDH17 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253963 |
|
|
Homo sapiens |
HEP-3B Cell, MHCC-97 Cell |
| pmid |
sentence |
| 20568120 |
The present study aims to identify the transcription factors which interact and regulate CDH17 promoter activity that might contribute to the up-regulation of CDH17 gene in human HCC|we identified hepatic nuclear factor 1α (HNF1α) and caudal-related homeobox 2 (CDX2) binding sites at the proximal promoter region which modulate the CDH17 promoter activities in two HCC cell lines (Hep3B and MHCC97L) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
MUC2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253966 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12559945 |
COS-7 cells were transiently transfected with a CDX1 or CDX2 expression construct and then used for the luciferase assay, reverse transcription-polymerase chain reaction, and electrophoretic mobility shift assay (EMSA). The CDX2 expression construct activated the MUC2 promoter and increased the endogenous MUC2 mRNA level, while the CDX1 one did not. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CDX2 | up-regulates quantity by expression
transcriptional regulation
|
MEP1A |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22326557 |
TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis| |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates quantity by repression
transcriptional regulation
|
CDX2 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253322 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15240568 |
SOX9 represses the expression of the CDX2 transcription factor, known to be mostly active in villus cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU5F1 | down-regulates quantity by repression
transcriptional regulation
|
CDX2 |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254933 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17068183 |
To enhance our understanding of the molecular basis of this differentiation event in humans, we used a functional genomics approach involving RNA interference-mediated suppression of OCT4 function in a human ESC line and analysis of the resulting transcriptional profiles to identify OCT4-dependent genes in human cells. We detected altered expression of >1,000 genes, including targets regulated directly by OCT4 either positively (NANOG, SOX2, REX1, LEFTB, LEFTA/EBAF DPPA4, THY1, and TDGF1) or negatively (CDX2, EOMES, BMP4, TBX18, Brachyury [T], DKK1, HLX1, GATA6, ID2, and DLX5), as well as targets for the OCT4-associated stem cell regulators SOX2 and NANOG. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CDX2
- 
- 