Summary

Name PKMYT1
Full Name Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Synonyms Myt1 kinase | MYT1
Primary ID Q99640
Links - -
Type protein
Relations 5
Function Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation PKMYT1 0.48
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.56
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PKMYT1 0.12
Publications: 1 Organism: Homo Sapiens