Summary

Name LYST
Full Name Lysosomal-trafficking regulator
Synonyms Beige homolog | CHS, CHS1
Primary ID Q99698
Links - -
Type protein
Relations 3
Function Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733).

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Relations

Regulator Mechanism target score ℹ
+ LYSTdown-regulates activity img/direct_inhibition.png binding RAB5A 0.267
Publications: 1 Organism: Drosophila Melanogaster
+ LYSTdown-regulates activity img/direct_inhibition.png binding RAB5C 0.2
Publications: 1 Organism: Drosophila Melanogaster
+ LYSTdown-regulates activity img/direct_inhibition.png binding RAB5B 0.2
Publications: 1 Organism: Drosophila Melanogaster