Summary

Name RBBP8
Full Name DNA endonuclease RBBP8
Synonyms CtBP-interacting protein, CtIP, Retinoblastoma-binding protein 8, RBBP-8, Retinoblastoma-interacting protein and myosin-like, RIM, Sporulation in the absence of SPO11 protein 2 homolog, SAE2 | CTIP
Primary ID Q99708
Links - -
Type protein
Relations 14
Function Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811, PubMed:10910365, PubMed:15485915, PubMed:16581787, PubMed:16818604, PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:20829486). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation RBBP8 0.547
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RBBP8 0.823
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RBBP8 0.603
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RBBP8 0.6
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding BRCA1-C complex 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png relocalization BRCC ubiquitin ligase complex 0.593
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATM 0.823
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination RBBP8 0.286
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization BRCA1 0.836
Publications: 1
+ up-regulates img/direct-activation.png ubiquitination RBBP8 0.836
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deubiquitination RBBP8 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SPEN 0.517
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding RBBP8 0.491
Publications: 1 Organism: Homo Sapiens